Synthesis of Some New Substituted Aminoacylthiazoles and Dipeptide Derivatives

Abstract

Coupling of N-phthalyl- or N-tosylamino acids with 4-p-tolyl- (or 4-p-chlorophenyl-) 2-aminothiazole (I-II) using the dicyclohexylcarbodiimide (DCC) method furnishes 2-(N-phthalyl- or N-tosylaminoacyl) amino-4-p-tolyl-thiazoles (III -XII) and the corresponding 4-p-chlorophenylthiazoles (XXIII-XXXII). Hydrazinolysis of 2-(N-phthalylaminoacyl) amino-4-p-tolyl-(or 4-p-chloraphenyl-) thiazoles (III-VII and XXIII-XXVIII) in ethanol afforded the desired 2-(aminoacyl) amino-4-p-tolyl-or (4-p-chlorophenyl-) thiazoles (XIII-XVII and XXXIII-XXXVII). 2-(N-Tosyldipeptidyl) amino-4-p-tolyl-( or 4-p-chlorophenyl-thiazoles (XVIII-XXII and XXXVIII-XLII) were synthesized via the DCC method. Some of the synthesized compounds were found to be active against a number of micro-organisms.