Effect of L-Glutamate, L-Glutamine and γ-Aminobutyric Acid on Glucose Metabolism in Cerebral Cortical Slices of Albino Rats

Abstract

Addition of L-glutamate decreases the C¹⁴ incorporation of U-C¹⁴ glucose into glycogen and carbon dioxide by cerebral cortical slices of normal rats and much more markedly by slices of diabetic rats. A similar effect could be demonstrated by the administration of glutamate intraperitonially. However, glutamine and γ-amino butyric acid which are closely related to glutamate do not have any effect under identical conditions both in vivo and in vitro.