Physicochemical Studies of the Interaction of an Antimalarial Drug Amodiaquine Hydrochloride with metal Ions of Biological Importance

Abstract

Octahedral complexes of Fe(III), Co(II) and Ni(II) with an antimalarial drug amodiaquine hydrochloride have been prepared. The complexes contain two molecules of the amodiaquine, which functions as a tridentate monoprotic ligand coordinating through quinoline nitrogen, tertiary nitrogen of diethyl moiety and by deprotonation of hydroxyl group. The drug precipitates quantitatively in a particular pH range which provides a new method for the microestimation of the drug as its complex.