Box-Behnken Experimental Design for Extraction of Spinosin from Ziziphus mauritiana Lam. Seeds

Quang Thuong Tran; Loan Thi Thanh Vu; Tram Huyen Le; Ly Thi Phuong Giang; Toyonobu Usuki

doi:10.14233/ajchem.2019.21763

Issue

Vol. 31 No. 5 (2019): Vol 31 Issue 5

Issue Published : March 28, 2019

This work is licensed under a Creative Commons Attribution 4.0 International License.

Box-Behnken Experimental Design for Extraction of Spinosin from Ziziphus mauritiana Lam. Seeds

https://doi.org/10.14233/ajchem.2019.21763

Quang Thuong Tran

Department of Organic Chemistry, Hanoi University of Science and Technology, 1 Dai Co Viet Road, Hanoi, Vietnam

Loan Thi Thanh Vu

Phu Tho Medical College, Truong Thinh, Phu Tho, Vietnam

Tram Huyen Le

Department of Organic Chemistry, Hanoi University of Science and Technology, 1 Dai Co Viet Road, Hanoi, Vietnam

Ly Thi Phuong Giang

Department of Organic Chemistry, Hanoi University of Science and Technology, 1 Dai Co Viet Road, Hanoi, Vietnam

Toyonobu Usuki

Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan

Corresponding Author(s) : Quang Thuong Tran

ttquang77ocd@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 5 (2019): Vol 31 Issue 5
Article Published : March 28, 2019

Abstract

The objective of this study was to evaluate the effects of extraction parameters (ethanol concentration, extraction ratio of solvent to raw material and extraction time) on the yield of spinosin from the seeds of Ziziphus mauritiana Lam. Box-Behnken factorial design was used in association with response surface methodology. The optimal extraction conditions were an ethanol concentration of 61 %, 40 (v/w) liquid-to-solid ratio, and 2.6 h extraction time with reflux. Spinosin was purified using Diaion HP20SS as an adsorbent. The maximum spinosin yield was 1.18 mg/g raw material. Present findings can be applied to future approaches for maximizing the extraction of spinosin from Z. mauritiana Lam. seeds.

Keywords

Box-Behnken design Extraction Spinosin Ziziphus mauritiana Lam.

Tran, Q. T., Thanh Vu, L. T., Le, T. H., Phuong Giang, L. T., & Usuki, T. (2019). Box-Behnken Experimental Design for Extraction of Spinosin from Ziziphus mauritiana Lam. Seeds. Asian Journal of Chemistry, 31(5), 1045–1048. https://doi.org/10.14233/ajchem.2019.21763

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References

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References

C.J. Ji, G.Z. Zeng, J. Han, W.J. He, Y.M. Zhang and N.H. Tan, Bioorg. Med. Chem. Lett., 22, 6377 (2012); https://doi.org/10.1016/j.bmcl.2012.08.074.

Y.L.Chen and B.K. Zhou, in Flora of China, Science Press: Beijing, vol. 48, pp. 131-146 (1982).

D.T. Loi, The Medicinal Plants and Herbs in Vietnam, Medical Publishing, Ha Noi: Vietnam, pp. 446-447 (2004).

K.H. Shin, C.K. Lee, W.S. Woo and S.S. Kang, Arch. Pharm. Res., 1, 7 (1978); https://doi.org/10.1007/BF02856299.

K. Kawashima, K. Saito, A. Yamada, S. Obara, T. Ozaki and Y. Kano, Biol. Pharm. Bull., 20, 1171 (1997); https://doi.org/10.1248/bpb.20.1171.

L.-E. Wang, Y.-J. Bai, X.-R. Shi, X.-Y. Cui, S.-Y. Cui, F. Zhang, Q.-Y. Zhang, Y.-Y. Zhao and Y.-H. Zhang, Pharmacol. Biochem. Behav., 90, 399 (2008); https://doi.org/10.1016/j.pbb.2008.03.022.

L.-E. Wang, X.-Y. Cui, S.-Y. Cui, J.-X. Cao, J. Zhang, Y.-H. Zhang, Q.-Y. Zhang, Y.-J. Bai and Y.-Y. Zhao, Phytomedicine, 17, 404 (2010); https://doi.org/10.1016/j.phymed.2010.01.014.

I.H. Jung, H.E. Lee, S.J. Park, Y.J. Ahn, G. Kwon, H. Woo, S.Y. Lee, J.S. Kim, Y.-W. Jo, D.S. Jang, S.S. Kang and J.H. Ryu, Pharmacol. Biochem. Behav., 120, 88 (2014); https://doi.org/10.1016/j.pbb.2014.02.015.

S.Y. Ko, H.E. Lee, S.J. Park, S.J. Jeon, B. Kim, Q. Gao, D.S. Jang and H. Ryu, Biomol. Ther., 23, 156 (2015); https://doi.org/10.4062/biomolther.2014.110.

Z. Erbay and F. Icier, J. Food Eng., 91, 533 (2009); https://doi.org/10.1016/j.jfoodeng.2008.10.004.

B. Yang, X. Liu and Y.X. Gao, Innov. Food Sci. Emerg. Technol., 10, 610 (2009); https://doi.org/10.1016/j.ifset.2009.03.003.

Issue

Vol. 31 No. 5 (2019): Vol 31 Issue 5

Box-Behnken Experimental Design for Extraction of Spinosin from Ziziphus mauritiana Lam. Seeds

Corresponding Author(s) : Quang Thuong Tran

Abstract

Keywords

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