Structural and Antimicrobial Studies of Some Newly Synthesised Complexes of Cobalt(II) of Bioinorganic Relevance

Abstract

Five new complexes of cobalt(II) have been synthesised by the interaction of fluphenazine (FPH) with cobalt(II) chloride, bromide, perchlorate, acetate or sulphate. The complexes which have been found to possess a stoichiometric composition of [CO(C₂₂H₂₆F₃N₃OS)(H₂O)₂X₂] have been characterised for their purity with the help of elemental studies, conductivity and magnetic measurements. An octahedral structure has been proposed based on thermal. electronic and IR spectral data. The new complexes have been tested in vitro for their antimicrobial activity against Alternaria alternata,  Aspergillus flavus, Escherichia coli and Staphyulcoccus aureus. The antibacterial activity of the cobalt(II) complexes against E. coli and S. aureus increases in the order: sulphate> chloride> perchlorate.