Synthesis and Biological Activity of Some N-Substituted Organic Phosphorotriamidates

Abstract

In present communication, we describe the synthesis of N,N,'N"-trio-o-methoxy phenyl phosphorotriamidate, N,N',N"-tri-o-ethoxy phenyl phosphorotriamidate and 3,4-dichloro-N,N',N"-triphenyl phosphoro triamidate by phosphorylation method. These phosphorotriamidates were used for screening effect on some selected species of fungi (Mucor mucedo, Pythium aphadermatam and Rhizoctonia solani) and bacteria (E. coli, Shigella boydii and Citrobacter frundi) in minimum concentration 0.0005 M in dioxane-water mixture (20:80 v/v).