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Vol. 32 No. 5 (2020): Vol 32 Issue 5

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Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives

Vijay Kumar Sharma
Amity Institute of Applied Sciences, Amity University Uttar Pradesh, Noida-201313, India; Integral Bio Sciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II Noida-201306, India
Anup Barde
Integral Bio Sciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II Noida-201306, India
Sunita Rattan
Amity Institute of Applied Sciences, Amity University Uttar Pradesh, Noida-201313, India

Corresponding Author(s) : Anup Barde

anup.barde@ibs.net.in

Asian Journal of Chemistry, Vol. 32 No. 5 (2020): Vol 32 Issue 5

Abstract

Novel thiazolidine-2,4-dione (TZD) based pyrimidine derivatives have been synthesized by Knoevenagel condensation reaction between thiazolidine-2,4-dione and amino pyrimidinyl aliphatic aldehydes followed by heterogeneous metal reduction. Synthetic strategy involved nucleophillic substitution of hydroxyl protected six membered aliphatic chain on 4,6-dichloropyrimidine followed by Suzuki coupling. This approach is regioselective, efficient and versatile for synthesis of such analogs.

Keywords

Thiazolidine-2,4-dione Suzuki coupling Knoevenagel condensation
Sharma, V. K., Barde, A., & Rattan, S. (2020). Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives. Asian Journal of Chemistry, 32(5), 1101–1108. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/2437
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