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Vol. 32 No. 6 (2020): Vol 32 Issue 6

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Novel Mixed Complexes Derived from Benzoimidazolphenylethanamine and 4-(Benzoimidazol-2-yl)aniline: Synthesis, Characterization, Antibacterial Evaluation and Theoretical Prediction of Toxicity

https://doi.org/10.14233/ajchem.2020.22472
Lotfi M. Aroua
Department of Chemistry, College of Science, Qassim University, Campus University, King Abdulaziz Road, P.O.Box: 6644, Buraydah, Qassim, Kingdom of Saudi Arabia; Laboratory of Organic Structural Chemistry & Macromolecules, Department of Chemistry, Faculty of Sciences of Tunis, Tunis El-Manar University, El Manar I 2092, Tunis, Tunisia
https://orcid.org/0000-0002-4471-6137

Corresponding Author(s) : Lotfi M. Aroua

aroua.lotfi@yahoo.com

Asian Journal of Chemistry, Vol. 32 No. 6 (2020): Vol 32 Issue 6

Abstract

Benzoimidazolphenylethanamine (BPE) has been synthesized using condensation reaction from o-phenyldiamine and L-phenylalanine. Some metal complexes have been synthesized from 4-(benzoimidazol-2-yl)aniline, benzoimidazolylphenylethanamine and cadmium(II), tin(II), copper(II) and nickel(II) metal in a molar ratio (1:1:1). All new metal complexes were characterized by spectroscopic data of FTIR, UV-visible electronic absorption, X-ray powder diffraction and thermal analysis. Spectra analysis of the mixed metal complexes showed the coordination of ligands to the metal ions via nitrogen atoms. The XRD powder showed that metal complexes have a monoclinic system. The preliminary tested in vitro antibacterial activities of Sn(II) complex was assayed against four bacterial isolates namely Micrococcus luteus, Staphylococcus aureus as Gram-positive, Pseudomonas aerugmosa and Escherichia coli.

Keywords

Benzoimidazolylphenylethanamine Mixed complexes Thermal stability Antimicrobial agents
Aroua, L. M. (2020). Novel Mixed Complexes Derived from Benzoimidazolphenylethanamine and 4-(Benzoimidazol-2-yl)aniline: Synthesis, Characterization, Antibacterial Evaluation and Theoretical Prediction of Toxicity. Asian Journal of Chemistry, 32(6), 1266–1272. https://doi.org/10.14233/ajchem.2020.22472
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