Copyright (c) 2020 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Structure Elucidation of New Flavone and Antioxidant, Anti-Inflammatory Activities from Leaves of Vitex negundo Linn.
Corresponding Author(s) : R. Manivannan
Asian Journal of Chemistry,
Vol. 32 No. 5 (2020): Vol 32 Issue 5
Abstract
A medicinally active chemical investigation on the leaves of Vitex negundo induce the confinement and identification of flavones apigenin (1), kaempferol (2) and one new flavone 5,7,4′-trihydroxy-3,3′,6,8-tetramethoxy flavone (3) and one known and rare flavone 5,7,4′-trihydroxy-6,3′,5′-trimethoxyflavone (4). These compounds composition were well-established on account of chromatography and spectroscopic sign and correlation with literature data. Antioxidant and carrageenan-induced paw edema in male albino rats were determined. Compounds 1 and 2 exhibited the most potent antioxidant effect at a dose of 200 mg/kg. Compound 1 produced noticeable anti-inflammatory effects (2.66 ± 0.08 at 3 h of injection) lightly off that of other compounds.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- R.A. Prabhu and A.P. Rajan, J. Pharm. Res., 3, 1920 (2010).
- A.S. Ravipati, L. Zhang, S.R. Koyyalamudi, S.C. Jeong, J. Bartlett, N. Reddy, P.T. Smith, K. Shanmugam, G. Münch, M. Satyanarayanan, M.J. Wu and B. Vysetti, BMC Complement. Altern. Med., 12, 1192 (2012); https://doi.org/10.1186/1472-6882-12-173
- A.M. Aljadi and M.Y. Kamaruddin, Food Chem., 85, 513 (2004); https://doi.org/10.1016/S0308-8146(02)00596-4
- J.A. Oates, A.J.J. Wood, P.M. Brooks and R.O. Day, N. Engl. J. Med., 324, 1716 (1991); https://doi.org/10.1056/NEJM199106133242407
- A.S. Mehanna, Am. J. Pharm. Educ., 67, 63 (2003); https://doi.org/10.5688/aj670263
- P.V. Diwan, I. Karwande, I. Margaret and P.B. Sattur, Indian J. Pharmacol., 21, 1 (1989).
- R. Manivannan, J. Pharm. Pharmacogn. Res., 4, 54 (2016).
- T.J. Mabry, K.R. Markham and M.B. Thomas, Systematic Identification of Flavonoids, Springer-Verlag: New York (1970).
- K.R. Markham, Techniques of Flavonoid Identification, Academic Press: London (1982).
- H.N. El-Sayed, M.A. Omara, K.A. Yousef, M.T. Farag and J. Mabry, Phytochemistry, 57, 575 (2001); https://doi.org/10.1016/S0031-9422(00)00479-9
- A. Gangwal, S.K. Parmar and N.R. Sheth, Schol. Res. Lib., 2, 307 (2010).
- E.C. Bate-Smith, J.B. Harborne and S.M. Davenport, Nature, 212, 1065 (1966); https://doi.org/10.1038/2121065a0
- T.J. Chen, J.Y. Jeng, C.W. Lin, C.Y. Wu and Y.C. Chen, Toxicology, 223, 113 (2006); https://doi.org/10.1016/j.tox.2006.03.007
- J.N. Roitman and L.F. James, Phytochemistry, 24, 835 (1985); https://doi.org/10.1016/S0031-9422(00)84904-3
- W. Herz, S.V. Govindan, I. Riess-Maurer, B. Kreil, H. Wagner, L. Farkas and J. Strelisky, Phytochemistry, 19, 669 (1980); https://doi.org/10.1016/0031-9422(80)87035-X
- C.A. Winter, E.A. Risley and G.W. Nuss, Proc. Soc. Exp. Biol. Med., 111, 544 (1962); https://doi.org/10.3181/00379727-111-27849
- R. Manivannan and R. Shopna, Nat. Prod. Sci., 23, 69 (2017); https://doi.org/10.20307/nps.2017.23.1.69
- A.D. Sedgwick and P. Lees, Agents Actions, 18, 429 (1986); https://doi.org/10.1007/BF01965008
- F. Nantel, D. Denis, R. Gordon, A. Northey, M. Cirino, K.M. Metters and C.C. Chan, Br. J. Pharmacol., 128, 853 (1999); https://doi.org/10.1038/sj.bjp.0702866
References
R.A. Prabhu and A.P. Rajan, J. Pharm. Res., 3, 1920 (2010).
A.S. Ravipati, L. Zhang, S.R. Koyyalamudi, S.C. Jeong, J. Bartlett, N. Reddy, P.T. Smith, K. Shanmugam, G. Münch, M. Satyanarayanan, M.J. Wu and B. Vysetti, BMC Complement. Altern. Med., 12, 1192 (2012); https://doi.org/10.1186/1472-6882-12-173
A.M. Aljadi and M.Y. Kamaruddin, Food Chem., 85, 513 (2004); https://doi.org/10.1016/S0308-8146(02)00596-4
J.A. Oates, A.J.J. Wood, P.M. Brooks and R.O. Day, N. Engl. J. Med., 324, 1716 (1991); https://doi.org/10.1056/NEJM199106133242407
A.S. Mehanna, Am. J. Pharm. Educ., 67, 63 (2003); https://doi.org/10.5688/aj670263
P.V. Diwan, I. Karwande, I. Margaret and P.B. Sattur, Indian J. Pharmacol., 21, 1 (1989).
R. Manivannan, J. Pharm. Pharmacogn. Res., 4, 54 (2016).
T.J. Mabry, K.R. Markham and M.B. Thomas, Systematic Identification of Flavonoids, Springer-Verlag: New York (1970).
K.R. Markham, Techniques of Flavonoid Identification, Academic Press: London (1982).
H.N. El-Sayed, M.A. Omara, K.A. Yousef, M.T. Farag and J. Mabry, Phytochemistry, 57, 575 (2001); https://doi.org/10.1016/S0031-9422(00)00479-9
A. Gangwal, S.K. Parmar and N.R. Sheth, Schol. Res. Lib., 2, 307 (2010).
E.C. Bate-Smith, J.B. Harborne and S.M. Davenport, Nature, 212, 1065 (1966); https://doi.org/10.1038/2121065a0
T.J. Chen, J.Y. Jeng, C.W. Lin, C.Y. Wu and Y.C. Chen, Toxicology, 223, 113 (2006); https://doi.org/10.1016/j.tox.2006.03.007
J.N. Roitman and L.F. James, Phytochemistry, 24, 835 (1985); https://doi.org/10.1016/S0031-9422(00)84904-3
W. Herz, S.V. Govindan, I. Riess-Maurer, B. Kreil, H. Wagner, L. Farkas and J. Strelisky, Phytochemistry, 19, 669 (1980); https://doi.org/10.1016/0031-9422(80)87035-X
C.A. Winter, E.A. Risley and G.W. Nuss, Proc. Soc. Exp. Biol. Med., 111, 544 (1962); https://doi.org/10.3181/00379727-111-27849
R. Manivannan and R. Shopna, Nat. Prod. Sci., 23, 69 (2017); https://doi.org/10.20307/nps.2017.23.1.69
A.D. Sedgwick and P. Lees, Agents Actions, 18, 429 (1986); https://doi.org/10.1007/BF01965008
F. Nantel, D. Denis, R. Gordon, A. Northey, M. Cirino, K.M. Metters and C.C. Chan, Br. J. Pharmacol., 128, 853 (1999); https://doi.org/10.1038/sj.bjp.0702866