Synthesis and Antimicrobial Properties of 2-Substituted Mercapto-4,8-Dimethyloxazolo(4,5-C)Quinolines

Abstract

2-Mercapto-4,8-dimethyloxazolo(4,5-c)quinoline (lla) was produced by
the condensation of 3-amino-4-hydroxy-2,6-dimethyl quinoline (Ic) with
carbon disulphide in alkaline medium. The reaction of lIa with alkyl and
aralkyl halides offered the corresponding thioethers (llb-k). The compounds
synthesised were characterised by  their analytical and spectral
analyses. A few selected compounds were screened for their antimicrobial
properties.