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Vol. 32 No. 6 (2020): Vol 32 Issue 6

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Chemical Modifications of Guar Gum for Drug Delivery Applications: A Review

https://doi.org/10.14233/ajchem.2020.22607
Pankaj Giri
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway (NH-64), Rajpura-140401, India
Simran Kaur Zandu
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway (NH-64), Rajpura-140401, India
Inderbir Singh
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway (NH-64), Rajpura-140401, India

Corresponding Author(s) : Inderbir Singh

inderbir.singh@chitkara.edu.in

Asian Journal of Chemistry, Vol. 32 No. 6 (2020): Vol 32 Issue 6

Abstract

Guar gum is a natural excipient extracted from the plant seed of Cyamopsis tetragonolobus, belonging to the Leguminosae family. In the pharmaceutical industries, it contributes an important role due to its non-toxicity, ease of availability, biodegradability and eco-friendly nature. The major constituents of guar gum is galactomannan which is composed of D-galactose anhydride and mannose anhydride. Hydroxyl groups present in galactomannan can be modified by carboxymethylation, grafting or cross-linking with other excipients for developing modified polymers having desirable properties. Guar gum is commonly used as a suspending, emulsifying, stabilizing, gelling and thickening agent in various dosage forms. The guar gum derivatives are also useful in controlling the drug release from the pharmaceutical dosage forms. In this review, different aspects of synthesis of guar gum derivatives and its applications in various drug delivery systems is described.

Keywords

Guar gum Chemical modification Drug delivery
Giri, P., Zandu, S. K., & Singh, I. (2020). Chemical Modifications of Guar Gum for Drug Delivery Applications: A Review. Asian Journal of Chemistry, 32(6), 1259–1265. https://doi.org/10.14233/ajchem.2020.22607
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