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Vol. 32 No. 7 (2020): Vol 32 Issue 7

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Synthesis and Spectral Studies of 4,4'-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2-methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

Anita Rani
Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala-134007, India
Manoj Kumar
Department of Biotechnology, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala-133207, India
Hardeep Singh Tuli
Department of Biotechnology, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala-133207, India
Zahoor Abbas
Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala-134007, India
Vinit Prakash
Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala-134007, India

Corresponding Author(s) : Manoj Kumar

manojraju27@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 7 (2020): Vol 32 Issue 7

Abstract

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

Keywords

p-Vanillin Schiff base Hydrazine hydrate Antimicrobial activity Anti-angiogenic activity DNA-photocleavage activity
Rani, A., Kumar, M., Tuli, H. S., Abbas, Z., & Prakash, V. (2020). Synthesis and Spectral Studies of 4,4’-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2-methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities. Asian Journal of Chemistry, 32(7), 1768–1772. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/2407
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