Synthesis and Characterization of Novel Analogues of Cefpodoxime Proxetil

Peketi Rajesh Reddy; Sivanadh Musunuri; D. Ramasekhara Reddy; V. Subrahmanyam Chittala; P.V.N.S. Murthy; K. Krishnamohan

Issue

Vol. 32 No. 7 (2020): Vol 32 Issue 7

Issue Published : June 27, 2020

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Characterization of Novel Analogues of Cefpodoxime Proxetil

Peketi Rajesh Reddy

Research and Development Department, Monvi Labs, 3rd floor, Plot No. 97, Road No. 9, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India; Department of Chemistry, Krishna University, Machilipatnam-521001, India

https://orcid.org/0000-0003-3736-2534

Sivanadh Musunuri

Department of Chemistry, Krishna University, Machilipatnam-521001, India

D. Ramasekhara Reddy

Department of Chemistry, Krishna University, Machilipatnam-521001, India

V. Subrahmanyam Chittala

Research and Development Department, Monvi Labs, 3rd floor, Plot No. 97, Road No. 9, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India

P.V.N.S. Murthy

Research and Development Department, Monvi Labs, 3rd floor, Plot No. 97, Road No. 9, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India

K. Krishnamohan

Research and Development Department, Monvi Labs, 3rd floor, Plot No. 97, Road No. 9, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India

Corresponding Author(s) : Peketi Rajesh Reddy

rajeshpeketi1979@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 7 (2020): Vol 32 Issue 7
Article Published : June 27, 2020

Abstract

The present work describes the origin, identification, synthesis, characterization and control of four novel analogues of cefpodoxime proxetil, which are ethyl, methyl, propyl and N-propyl analogues of cefpodoxime proxetil.

Keywords

Cefpodoxime proxetil Cephlosporin Novel analogues

Reddy, P. R., Musunuri, S., Reddy, D. R., Chittala, V. S., Murthy, P., & Krishnamohan, K. (2020). Synthesis and Characterization of Novel Analogues of Cefpodoxime Proxetil. Asian Journal of Chemistry, 32(7), 1751–1755. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/2400

Download Citation

References

International Conference on Harmonization (ICH) Guidelines Q3A (R) Impurities in New Drug Substances; ICH Guidelines: Geneva, Switzerland, February (2002).
International Conference on Harmonization (ICH) Guidelines Q2B Validation of Analytical Procedure: Methodology, Geneva, Switzerland, November (1996).
M.J. Wang, W.B. Zou, J. Xue and C. Hu, Chromatohraphia, 65, 69 (2006); https://doi.org/10.1365/s10337-006-0113-6
N. Fukutsu, T. Kawasaki, K. Saito and H. Nakazawa, J. Chromatogr. A, 1129, 153 (2006); https://doi.org/10.1016/j.chroma.2006.06.102
E. Biçer, N. Özdemir and S. Özdemir, Croat. Chem. Acta, 86, 49 (2013); https://doi.org/10.5562/cca2071
J. Li, D. Zhang and C. Hu, Acta Pharm. Sin. B, 4, 322 (2014); https://doi.org/10.1016/j.apsb.2014.06.007
A.V. Raghava Reddy, G. Srinivas, T. Chandiran, A. Naidu and D. Ramesh, Indo-Am. J. Pharm. Res., 5, 2239 (2015).
W. Jian and W. Chengfa, Zhongguo Yiyao Gongye Zazhi, 33, 450 (2002).
European Pharmacopoeia 7.0, 1618-1620.
H. Nakao, K. Fujimoto, S. Ishihara, S. Sugawara and I. Igarashi, Process for the Preparation of Cefpodoxime Proxetil, US Patent 4,486,425 (1993).
W.J. Kim, K.Y. Ko, M.H. Jung, M. Kim, K.I. Lee and J.H. Kim, J. Antibiot. (Tokyo), 44, 1083 (1991); https://doi.org/10.7164/antibiotics.44.1083
Y. Kumar, M. Prasad, K. Singh and S. Misra, Cefpodixime Proxetil, US Patent 7,045,618B2 (2002).
H. Poras, E. Bonnard, E. Dangé, M.-C. Fournié-Zaluski and B.P. Roques, J. Med. Chem., 57, 5748 (2014); https://doi.org/10.1021/jm500602h
D.A. Flosser and R.A. Olofson, Synth. Commun., 33, 2045 (2003); https://doi.org/10.1081/SCC-120021030
F. Daeyaert and B.J. Van der Veken, J. Mol. Struct., 198, 239 (1989); https://doi.org/10.1016/0022-2860(89)80042-0
T. Takao, T. Hisashi, M. Takashi, Y. Hideaki and K. Koji, Eur. Patent No. EP 29557 (1981).
T. Takao, T. Hisashi, M. Takashi, Y. Hideaki and K. Koji, Patent No. US 4409215 (1983).
H. Nakao, K. Fujimoto, S. Ishihara, S. Sugawara and I. Igarashi, Patent No. EP 49118 (1982).

References

International Conference on Harmonization (ICH) Guidelines Q3A (R) Impurities in New Drug Substances; ICH Guidelines: Geneva, Switzerland, February (2002).

International Conference on Harmonization (ICH) Guidelines Q2B Validation of Analytical Procedure: Methodology, Geneva, Switzerland, November (1996).

M.J. Wang, W.B. Zou, J. Xue and C. Hu, Chromatohraphia, 65, 69 (2006); https://doi.org/10.1365/s10337-006-0113-6

N. Fukutsu, T. Kawasaki, K. Saito and H. Nakazawa, J. Chromatogr. A, 1129, 153 (2006); https://doi.org/10.1016/j.chroma.2006.06.102

E. Biçer, N. Özdemir and S. Özdemir, Croat. Chem. Acta, 86, 49 (2013); https://doi.org/10.5562/cca2071

J. Li, D. Zhang and C. Hu, Acta Pharm. Sin. B, 4, 322 (2014); https://doi.org/10.1016/j.apsb.2014.06.007

A.V. Raghava Reddy, G. Srinivas, T. Chandiran, A. Naidu and D. Ramesh, Indo-Am. J. Pharm. Res., 5, 2239 (2015).

W. Jian and W. Chengfa, Zhongguo Yiyao Gongye Zazhi, 33, 450 (2002).

European Pharmacopoeia 7.0, 1618-1620.

H. Nakao, K. Fujimoto, S. Ishihara, S. Sugawara and I. Igarashi, Process for the Preparation of Cefpodoxime Proxetil, US Patent 4,486,425 (1993).

W.J. Kim, K.Y. Ko, M.H. Jung, M. Kim, K.I. Lee and J.H. Kim, J. Antibiot. (Tokyo), 44, 1083 (1991); https://doi.org/10.7164/antibiotics.44.1083

Y. Kumar, M. Prasad, K. Singh and S. Misra, Cefpodixime Proxetil, US Patent 7,045,618B2 (2002).

H. Poras, E. Bonnard, E. Dangé, M.-C. Fournié-Zaluski and B.P. Roques, J. Med. Chem., 57, 5748 (2014); https://doi.org/10.1021/jm500602h

D.A. Flosser and R.A. Olofson, Synth. Commun., 33, 2045 (2003); https://doi.org/10.1081/SCC-120021030

F. Daeyaert and B.J. Van der Veken, J. Mol. Struct., 198, 239 (1989); https://doi.org/10.1016/0022-2860(89)80042-0

T. Takao, T. Hisashi, M. Takashi, Y. Hideaki and K. Koji, Eur. Patent No. EP 29557 (1981).

T. Takao, T. Hisashi, M. Takashi, Y. Hideaki and K. Koji, Patent No. US 4409215 (1983).

H. Nakao, K. Fujimoto, S. Ishihara, S. Sugawara and I. Igarashi, Patent No. EP 49118 (1982).

Issue

Vol. 32 No. 7 (2020): Vol 32 Issue 7

Synthesis and Characterization of Novel Analogues of Cefpodoxime Proxetil

Corresponding Author(s) : Peketi Rajesh Reddy

Abstract

Keywords

Full Article

Download Citation

References

Table Of Contents