Studies on Interaction of an Antimalarial Drug Pyrimethamine with Co(II), Ni(II) and Cu(II)

Abstract

The present communication describes the preparation and characterisation

of pyrimethamine (an antimalarial drug) complexes with Co(II),

Ni(II) and Cu(II) with the help of elemental analysis, magnetic susceptibility,

electronic and infrared spectral studies. 2 : 1 metal to drug

stoichiometry for Co(II) and Ni(II) and 1 : 2 metal to drug stoichiometry

for Cu(II) complexes have been confirmed by analytical data. From the

reflectance spectra octahedral geometry for Co(II), Ni(II) and Cu(II) complexes

has been assigned. Ligand field parameters (Dq. B and β) have been

calculated for the complexes.