A Novel Method for Synthesis of Pyrazolines and Pyrazoles

Abstract

Some new 3,5-diaryl pyrazolines and 3,5-diaryl pyrazoles have been synthesized by a novel method by short route. 3,5-Diaryl-1-pyridoyl pyrazolines (4) were synthesized by the reaction of 2-hydroxy acetophenones (1) with isoniazid in alcohol medium containing a little piperidine. 2-hydroxy acetophenones (1) on reacting
with phenyl hydrazine hydrochloride in alcohol medium containing
a little piperidine produces 3,5-diaryl-1-phenyl pyrazolines
(3). 2-Aroyl acetophenones (2) with phenylhydrazine hydrochloride
in alcohol medium containing a little piperidine produces 3,5-diaryl-1-
phenyl pyrazoles (5). Structures of these compounds have been
established by spectral analysis (IR, UV and NMR).