Issue

Vol. 32 No. 7 (2020): Vol 32 Issue 7

Copyright (c) 2020 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Reaction of Carbidopa with cis-[Cr(C2O4)2(H2O)2]− in Aqueous Medium: A Kinetic, Mechanistic and Antiparkinsonian Study of the Product Complex

Sudhanshu Sekhar Rout
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar- 751030, India
Durga Madhab Kar
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar- 751030, India
Sudam Chandra Si
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar- 751030, India
Ajaya Kumar Patnaik
Department of Chemistry, Ravenshaw University, Cuttack-753003, India
Prakash Mohanty
Department of Chemistry, Ravenshaw University, Cuttack-753003, India

Corresponding Author(s) : Sudhanshu Sekhar Rout

sudhanshurout@soa.ac.in

Asian Journal of Chemistry, Vol. 32 No. 7 (2020): Vol 32 Issue 7

Abstract

For the treatment of Parkinson′s disease, the second most common neurodegenerative disorder, requires a combination of levodopa with a peripheral decarboxylase inhibitor, such as carbidopa which provides a symptomatic relief to patients. Reaction of carbidopa with cis-[Cr(C2O4)2(H2O)2]– has been carried out in aqueous medium over the range 35 ≤ t ≤ 50 ºC, 4.0 ≤ pH ≤ 6.0 , 3.75 × 10-3 mol dm-3 ≤ [carbidopa] ≤ 9.38 × 10-3 mol dm-3, I (KNO3) = 0.1 mol dm-3. There is outersphere association between cis-[Cr(C2O4)2(H2O)2]– and conjugate base of carbidopa followed by first chelation. The characterization of the product was performed by using NMR and infrared spectroscopies. The product showed better antiparkinsonian activity than the combination of levodopa and carbidopa.

Keywords

Carbidopa cis-Diaquabis(oxalato)chromate(III) Kinetics Substitution Anti-parkinsonian drug
Rout, S. S., Kar, D. M., Si, S. C., Patnaik, A. K., & Mohanty, P. (2020). Reaction of Carbidopa with cis-[Cr(C2O4)2(H2O)2]− in Aqueous Medium: A Kinetic, Mechanistic and Antiparkinsonian Study of the Product Complex. Asian Journal of Chemistry, 32(7), 1653–1659. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/2386
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. M.J. Armstrong and M.S. Okun, JAMA, 323, 548 (2020); https://doi.org/10.1001/jama.2019.22360
  2. S.Z.A. Zaidi and N. Fatima, Eur. Chem. Bull., 3, 648 (2014); https://doi.org/10.17628/ECB.2014.3.648
  3. V.J. Lotti and C.C. Porter, J. Pharmacol. Exp. Ther., 172, 406 (1970).
  4. R.P. Lesser, S. Fahn, S.R. Snider, L.J. Cote, W.P. Isgreen and R.E. Barrett, Neurology, 29, 1253 (1979); https://doi.org/10.1212/WNL.29.9_Part_1.1253
  5. C.D. Marsden, J.D. Parkes and N. Quinn, eds.: C.D. Marsden and S. Fahn, Movement Disorders, Butterworth: London, p. 96 (1982).
  6. W. Lovenberg, H. Weissbach and S. Undenfriend, J. Biol. Chem., 237, 89 (1962).
  7. C. Borri-Voltattorni, A. Minelli and P. Borri, FEBS Lett., 75, 277 (1977); https://doi.org/10.1016/0014-5793(77)80102-6
  8. C.C. Porter, L.S. Watson, D.C. Titus, J.A. Totaro and S.S. Byer, J. Pharmacol., 11, 1067 (1962).
  9. J.R. Bianchine, F.S. Messiha and T.J. Preziosi, Adv. Neurol., 2, 101 (1973).
  10. M.E. Jaffe, Adv. Neurol., 2, 161 (1973).
  11. J. Cedarbaum, H. Kutt, A. Dhar, S. Watkins and F. McDowell, Clin. Neuropharmacol., 9, 153 (1986); https://doi.org/10.1097/00002826-198604000-00006
  12. S. Rao and D. Calne, Adv. Neurol., 3, 73 (1973).
  13. M. Szablowicz and E. Kita, Transition Metal Chem., 30, 623 (2005); https://doi.org/10.1007/s11243-005-4588-z
  14. M. Pazderska-Szablowicz, A. Bialkowska and E. Kita, Transition Met. Chem., 31, 413 (2006); https://doi.org/10.1007/s11243-006-0010-8
  15. B.K. Aziz and D.I. Tofiq, Int. J. Chem. Environ. Eng., 3, 34 (2012).
  16. I.A. Khan and Kabir-Ud-Din, J. Inorg. Nucl. Chem., 43, 1082 (1981); https://doi.org/10.1016/0022-1902(81)80188-1
  17. I.A. Khan and Kabir-ud-Din, Indian J. Chem., 23A, 98 (1984).
  18. I.A. Khan, M. Sahid and Kabir-ud-Din, Indian J. Chem., 22A, 382 (1983).
  19. S.C. Tyagi and A. Aziz Khan, J. Inorg. Nucl. Chem., 40, 1899 (1978); https://doi.org/10.1016/0022-1902(78)80251-6
  20. I.A. Khan and Kabir-Ud-Din, Int. J. Chem. Kinet., 17, 1263 (1985); https://doi.org/10.1002/kin.550171203
  21. I.A. Khan, M. Sahid and Kabir-ud-Din, J. Chem. Soc., Dalton Trans., 10, 3007 (1990).
  22. J.K. Dei, N.N. Pasupalak and P. Mohanty, Transition Met. Chem., 22, 516 (1997); https://doi.org/10.1023/A:1018579700786
  23. I.A. Khan, M. Sahid and Kabir-ud-Din, J. Indian Chem. Soc., 69, 864 (1992).
  24. D. Banerjea and S.D. Chaudhuri, J. Inorg. Nucl. Chem., 30, 871 (1968); https://doi.org/10.1016/0022-1902(68)80449-X
  25. Kabir-ud-Din and G.J. Khan, Proc. Indian Acad. Sci. (Chem. Sci.), 107, 11 (1995).
  26. M.A. Abdullah, J. Barrett and P. O’Brien, J. Chem. Soc., Dalton Trans., 8, 1647 (1984); https://doi.org/10.1039/dt9840001647
  27. B.K. Niogy and G.S. De, Proc. Indian Acad. Sci. (Chem. Sci.), 92, 153 (1983); https://doi.org/10.1007/BF02840725
  28. B.K. Niogy and G.S. De, Indian J. Chem., 24A, 208 (1985).
  29. R.E. Hamm, R.L. Johnson, R.N. Perkins and R.E. Davis, J. Am. Chem. Soc., 80, 4469 (1958); https://doi.org/10.1021/ja01550a008
  30. M.F. Abdel-Messih, J. Coord. Chem., 66, 1519 (2013); https://doi.org/10.1080/00958972.2013.779685
  31. V.C.H. Langford and H.B. Gray, Ligand Substitution Processes, W. A. Benjamin, Inc.: New York (1965).
  32. A.G. MacDiarmid, Inorganic Syntheses, McGraw-Hill Book Company: New York, vol. 17, p. 149 (1979).
  33. H.A. Adedeji, I.O. Ishola and O.O. Adeyemi, Prog. Neuropsychopharmacol. Biol. Psychiatry, 48, 245 (2014); https://doi.org/10.1016/j.pnpbp.2013.10.014
  34. Remington: The Science and Practice of Pharmacy, edn 22, vol. 1, p. 1310 (2013).
  35. T.W. Kallen and E.J. Senko, Inorg. Chem., 22, 2924 (1983); https://doi.org/10.1021/ic00162a032
  36. R.B. Jordan, Reaction Mechanism of Inorganic and Organometallic Systems, Oxford University Press: New York (1991).
  37. K. Nakamato, Infrared and Raman Spectra of Inorganic and Coordination Compounds, edn 5, John Wiley & Sons Inc. (1997).
  38. C.N.R. Rao, Chemical Application of Infrared Spectroscopy, Academic Press, New York (1963).
  39. I.A. Khan, M. Shahid and Kabir-ud-Din, Transition Met. Chem., 12, 393 (1987); https://doi.org/10.1007/BF01171644
  40. S. Mohanty, S. Anand, G.S. Brahma and P. Mohanty, J. Indian Chem. Soc., 80, 810 (2003).
  41. J. Behera, G.S. Brahma and P. Mohanty, J. Indian Chem. Soc., 78, 123 (2001).
  42. S.C. Dash, G.S. Brahma, R. Das, N.N. Das and P. Mohanty, Indian J. Chem., 45A, 2406 (2006).
  43. D.K. Baral, S.S. Rout, J. Behera, S.C. Si and P. Mohanty, Transition Met. Chem., 36, 231 (2011); https://doi.org/10.1007/s11243-011-9460-8
  44. S.S. Rout, D.M. Kar, S. Pattanaik, S.C. Si and P. Mohanty, Asian J. Chem., 29, 1555 (2017); https://doi.org/10.14233/ajchem.2017.20573
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0