Synthesis, Characterization and Cytotoxic Activity of New Plantinum(II) Complexes with Some Nitrogen Containing Ligands, Part (2): With 3,5-Dimethylpyrazole

Abstract

New platinum(II) complexes of the general formula cis-[PtLL'X₂], where L = L'- = 3,5-dimethylpyrazole, X = 0.5 C₂O₄ or 0.5 O₂(CO)₂C-CH₂CH₂CH₂CH₂ or O(CO)C₆H₁₁ and L = 3,5-dimethylpyrazole, L' = DMSO, X = Cl have been prepared as analogue to so called cisplatin, carboplatin (paraplatin) and ox-aliplatin; the known, anti-cancer drugs. The complexes obtained have been characterized physico-chemically and spectroscopically. The cytotoxic activities of these complexes have been studied against Hep-2, Hela, RD, L_20B, BGM and Vero cell lines using the MTT-colorimetric assay. These activities were compared with cytotoxic activities of three reference standards: the cisplatin, carboplatin and oxalipaltin complexes. The significance of the results obtained is discussed.