Synthesis, Characterisation, Antifungal and Antibacterial Studied of Nickel(II) and Silver(I) Complexes of Tridentate Bis Benzimidazoles

Abstract

Some biologically active tridentate bis benzimidazoles prepared

by the condensation of o-phenylene diamine with carboxylic acids

such as malic, thiomalic and furan 2,5-dicarboxylic acid and further

their 1 : 1 nickel(II) and silver(I) complexes have been described.

These ligands and their complexs were characterised on the basis

of elemental analyses, conductance measurement, molecular weight

determination, IR and (¹H and ¹³C) NMR spectral studies. Spectral

data supports distorted octahedral and distorted tetrahedral

geometries for nickel(II) and silver(I) complexes respectively. All

the newly synthesized ligands and their complexes have been

screened in vitro for antimicrobial activity against some of the

pathogenic fungi and bacteria at different concentrations. Results

of this screening have revealed that metal complexes exhibit more

enhanced activity than their parent ligands against both the fungal

and bacterial strains used.