Studied on Acoustical Properties of Diclofanac Sodium Methanol-Water System at 30 oC

Abstract

Ultrasonic velocity measurements of diclofanac sodium in methanol-water

(90 and 70% v/v) mixtures were carried out at 30ºC using a single

crystal multifrequency interferometer operating at 3 MHz. Various acoustical

parameters like β_ad, Z, L_f, R, R_A, r, b, π, ɸ_k and S_n were evaluated

using U, ρ and η data at 30ºC at different concentrations and interpreted

in terms of ion-solvent and ion-ion interactions. The drug has structure-breaking

tendency at low concentrations (< 0.02–0.01 M) and structure-making

tendency at higher concentrations. The solvation is maximum at

about 0.04, 0.06 and 0.08 M for pure methanol, 90% and 70% methanol

solutions.