Synthesis and Reactions of 2-Amino-4,6-Diaryl Pyrimidine Derivatives

Abstract

Variously substituted chalcones(I) were prepared by the Claisen-Schmidt

condensation of substituted acetophenones with aromatic

aldehydes which on treatment with guanidine nitrate (II) in presence

of base furnished 2-amino-4,6-diaryl pyrimidines (III). The reactions

of these compounds have been carried out with aromatic

aldehydes, acetic anhydride, phenyl isothiocyanate and benzoyl

isothiocyanate. Structures of the resultant compounds (IV), (V),

(VI) and (VII) have been confirmed on the basis of elemental

analysis and spectral data. Antibacterial activity of some of these

compounds has also been carried out.