Synthesis and Anti-inflammatory Activity of Steroidal Isoxazoles
Corresponding Author(s) : Devender Pathak
Asian Journal of Chemistry,
Vol. 10 No. 4 (1998): Vol 10 Issue 4
Abstract
The steroidal isoxazoles, 4-aza-5α-cholestano [3,2-c] isoxazole (2), 4-aza-5α-androstano [3,2-c] isoxazol-17β-yl acetate (4) and 17a-aza-Dhomo-5-androsteno [17,16-c] isoxazol-3β-yl acetate (6) have beenprepared and screened for their biological activity. The Compound 2(ED50 = 5.67 mg/kg), Compound 4 (ED50 = 2.97 mg/kg) and Compound 6(ED50 = 11.00 mg/kg) were found to be potent anti-inflammatory agents.
Keywords
Synthesis
Anti-inflammatory Activity
Steroidal Isoxazoles
Pathak, D., & Paul Jindal, D. (2010). Synthesis and Anti-inflammatory Activity of Steroidal Isoxazoles . Asian Journal of Chemistry, 10(4), 813–817. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/23730
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