Spectrophotometric Determination of Trifluoerazine hydrochloride

Abstract

Two spectrophotometric methods for the determination of trifluoperazinehydrochloride (TFP) either in pure or pharmacutical preparations havebeen developed based on its colour reaction with N-chlorosuccinimide(NCS) or with quinolinium chlorochromate (QCC) in acid medium. Beer'slaw is obeyed over the concentration range of 2-32 ppm with NCS and6-88 ppm with QCC. The slope, intercept and correlation coefficients areevaluated by linear-least squares method.  A study of the effect of thecommonly associated excipients revealed that they did not interfere. Statisticalanalysis of results indicates that the method is precise and accurate.