Synthesis of Some New 1-Carboxamido-3-(substituted-2-hydroxy phenyl)-5-aryl-Δ2-pyrazolines

Abstract

2'-Hydroxychalcone an aqueous solution of semicarbazidehydrochloride were refluxed in ethanol for 3 h. The reaction mixturewas cooled, filtered and crystallised from ethanol-acetic acid mixtureto get  1-carboxamido-3-(substituted-2-hydroxyphenyl)-5-aryldΔ² -pyrazoline. All these synthesised new pyrazolines were testedagainst organism. The Minimum Inhibitory Concentration (MIC)values were determind by using serial dilution method.