Synthesis, Characterization and Antimicrobial Studies of Some Macrocyclic Ligands and Their Nickel(II) Complexes

Abstract

18-Membered macrocyclic ligand 4,5;10, 11 ;16,17-B_zO₃-12, I5-dioxo-1 ,2,7,8-tetraaza-3,6-dione cycIooctadeca-8,18-diene.{(18) diene N₄O₄} and  19-membered 4,5;10,11;17,18-B_zO₃-12,16-dioxo-1,2,7,8-tetraaza-3,6-dione cyclonona-odeca-8,19-diene,{(19) diene N₄O₄} macrocyclic ligand having nitrogen and oxygenatoms as donor sites, have been used to synthesize Ni(II) complexesby template condensation reaction. In-vitro biocidal studies of thecomplexes and their constituting fragments against two bacteriaStaphylococcus aureus and Escherichia coli and two fungiAsperigillus niger and Candida albicans reveal that the macrocycIiccomplexes show greater antimicrobial activity in comparison toother constituting elements.