Kinetics and Mechanism of the oxidation of Some Tetracyclines by Chloramine-T
Corresponding Author(s) : R.N.P. Singh
Asian Journal of Chemistry,
Vol. 10 No. 2 (1998): Vol 10 Issue 2
Abstract
The oxidation of oxytetracycline hydrochloride and tetracyclinehydrochloride by chloramine-T (CAT) in aqueous acetic acid solutionleads to the fonnation of the corresponding decarboxylatedproduct. The reaction is first order with respect to the substrate aswell as with respect to H+ ion. The rate is independent of CATconcentration. Thennodynamic parameters have been calculatedand mechanistic steps discussed.
Keywords
Kinetics
Mechanism
Oxidation
Tetracyclines
Chloramine-T
(1)
Singh, R.; K. Sinha, A.; Singh, N. Kinetics and Mechanism of the Oxidation of Some Tetracyclines by Chloramine-T . ajc 2010, 10, 246-269.
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