Synthesis and Antibacterial Activity of 2-Amino-4-(2'4'-Dichloro-5'-Fluorophen-1'-yl)-6-Aryl Pyrimidine Derivatives and Related Compounds
Corresponding Author(s) : H.B. Naik
Asian Journal of Chemistry,
Vol. 11 No. 4 (1999): Vol 11 Issue 4
Abstract
2´,4´-Dichloro-5´-fluorochalcone (1a-j) react with an alcoholic solution of guanidine nitrate containing aqueous sodium hydroxide solution to give the corresponding 2-amino-4-(2´,4´-dichloro-5´-flurophen-1´-yl)-6-aryl pyramidines (2a-j). Compounds (2a-j)were converted to diacetyl (3a-j); sulphonamide (4a-j); and N-acetyl sulphonamide (5a-j) pyrimidine derivitives. These varied products have been characterised by spectral studies and screened for antibacterial activity.
Keywords
Synthesis
Antibacterial Activity
2-Amino-4-(2'4'-Dichloro-5'-Fluorophen-1'-yl)-6-Aryl Pyrimidine
Related Compounds
Bharucha, P., & Naik, H. (2010). Synthesis and Antibacterial Activity of 2-Amino-4-(2’4’-Dichloro-5’-Fluorophen-1’-yl)-6-Aryl Pyrimidine Derivatives and Related Compounds. Asian Journal of Chemistry, 11(4), 1553–1555. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/23534
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