Synthesis and Cytotoxic Activity of Some Novel trans-Palladium Complexes with Pyrazole Derivatives†

Abstract

Novel palladium(II) complex of the general formula trans-[PdL₂Cl₂], where L is pyrazole derivative, have been prepared and characterized physico-chemically and spectroscopically. It was shown that pyrazole derivative, have been prepared and characterized physico-chemically and spectroscopically. It was shown that pyrazole deivatives coordinate with palladium in a monodentate fashion via the most reactive nitrogen site. The cytotoxic activity of these complexes was evaluated in vitro against four cell-lines using the MTT-assay, one fluid suspension (P388, leukaemia) and three solid human cell lines (Hep-2, larynx; RD, embryonal rhabdomyosarcoma and HeLa, cervical cells). One of these complexes, for example, demonstrated a potent cytotoxic activity against P388 and significant cytotoxicity against the other three-cell lines in comparison with the reference standards: cisplatin, car- boplatin, oxaliplatin and 5-FU.