Diastereoselective Synthesis of Chiral Bicycle Phosphoramides Derived from (S)-2-(Anilinomethyl) pyrrolidine
Corresponding Author(s) : R.M. Baraka
Asian Journal of Chemistry,
Vol. 11 No. 4 (1999): Vol 11 Issue 4
Abstract
The diastereoselectivity of the chiral bicyclic phosphoramide synthesis can be improved under certain conditions of temperature and degree of polarity of the solvent. Measured diastereomer ratio (exo-isomer : endo-isomer) enhanced from (1.00 : 1.00) to (1.00 :1.44) in favourable cases. This enhancement in the diastereoselectivity
is highly relevant to the development of asymmetric synthesis,
where chiral bicyclic phosphoramides are used as catalysts.
Keywords
Diastereoselective Synthesis
Chiral Bicycle
Phosphoramides
(S)-2-(Anilinomethyl) pyrrolidine
El-Hendawi, H., Barrisford, D., Baraka, R., & El-Nehhal, I. (2010). Diastereoselective Synthesis of Chiral Bicycle Phosphoramides Derived from (S)-2-(Anilinomethyl) pyrrolidine. Asian Journal of Chemistry, 11(4), 1334–1342. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/23490
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