Synthesis and Antimicrobial Activity of 3-Substituted Phenyl-5-(5'-Substituted-2'-Phenylindol-3'-yl)-1,2-Diazoles and 3-Substituted Phenyl-5-(5'Substituted-2'-Phenylidol-3'-yl)-Isoxazoles

Abstract

5-Substituted-2-phenylindol-3-carboxaldehydes (Ia-c) were condensed

with substituted acetophenones (IIa-h) in ethylene glycol and catalytic

amount of piperidine afforded 5-substituted-2-phenylindol-3-chalcones

(IIIa-x). These compounds, on reaction with hydrazine hydrate in absolute

alcohol and hydroxylamine hydrochloride in alcoholic sodium hydroxide

yielded 3-substituted phenyl-5-(5´-substituted-2´-phenylindol-3´ -yl)-1,2-

diazoles (IVa-x) and 3-substituted phenyl-5-(5´-substituted-2-phenylindol-

3´-yl) isoxazoles (Va-x), respectively. The newly sysnthesised compounds

were characterised by their analytical and spectral data. All these compounds

were screened for antimicrobial activity against S. aureus, E. coli,

A. niger and C. albicans.