Synthesis and Antibacterial Activity of Substituted-3-Bromoflavanone

Abstract

A solution of 2´-hydroxy-5´-chloro-4-methoxy-α,β-dibromochalcone,

2´-hydroxy-5´-chloro-α,β-dibromochalcone, 2´-hydroxy-5´chloro-

3´-bromo-4-methoxy-α,β-dibromochalcone, 2´-hydroxy-5´-chloro-

3´-bromo-α,β-dibromochalcone, 2´-hydroxy-5´ -chloro-3´-nitro-

4-methoxy-α,β-dibromochalcone in acetic acid was refluxed

for 1 h, affords substituted-3-bromoflavanone. These compounds

are tested against test organism Staphylococous aureus, Streptococus

pyogenes, S. agaiactiae, S. faecalis, Corynebacterium ulcerans,

C. minatissimum, Clostridium septicum, Clostridium tetani

and Escherichia coli. The minimum inhibitory concentration (MIC)

values were determined by using serial dilution method.