Estimation of Atenolol and Nifedipine in Multicomponent Formulation by Ultraviolet Spectroscopy

Abstract

Spectrophotometric methods requiring no prior separation have

been proposed for simultaneous estimation of atenolol and

nifedipine in two component tablet and capsule formulations. The

methods employ first derivative spectrophotometry and ratio compensation

technique for the simultaneous analysis of the two drugs.

The absorbance maxima of atenolol was found to be at 276 nm and

that of nifedipine was at 340 nm, in 50% v/v aqueous methanol.

Atenolol and nifedipine obeyed Beer's law in the concentration

ranges employed for these methods. Results of analysis and

recovery studies were statistically evaluated for their accuracy and

precision.