Simultaneous Analysis of Tinidazole-Furazolidone Combination by UV-Spectrophotometry

Abstract

Two spectrophotometric methods have been developed for simultaneous

analysis of tinidazole and furazolidone in two component

suspension formulations. The methods are accurate, economical and

allow direct measurement of the drugs without any prior separation.

The absorbance maxima of tinidazole was found to be at 317 nm

and that of furazolidone was at 367 nm, in 15% v/v N,N-dimethylformamide.

The methods employ simultaneous equations and

graphical absorbance ratio method for their simultaneous estimation.

Both the drugs obey Beer's law in the concentration ranges

employed for these methods. The methods have been validated

statistically and by recovery studies.