Extractive Spectrophotometric Determination of Dextromethorphane Hydrobromide and Triprolidine Hydrochloride from Liquid Dasage Form

Abstract

Two accurate methods have been developed for the simultaneous

analysis of dextromethorphan hydrobromide and triprolidine hydrochloride

from liquid dosage forms. First method depends on derivative

spectrophotometry with zero crossing point technique of measurement,

whereas another method is based on measurement of absorbances of

sample solution at 278 and 300 nm. Beer's law is followed up to 180

μg/mL of dextromethorphan hydrobromide and 15 μg/mL of triprolidine

hydrochloride. The methods have been validated statistically and by

recovery studies.