Synthesis and Biological Activities of some New Series of Azoles

Abstract

The reactions of 2-naphthoxy acetate and ethyl salicylate with

hydrazine hydrate gave the corresponding hydrazides. Substituted

pyrazoles were synthesized by treating the carbohydrazides with

ethylacetoacetate, acetylacetone and ethylcyanoacetate. Cyclisation

of thiosemicarbazides under appropriate conditions afforded triazole

and thiadiazole derivatives. All the compounds were tested for their

antimicrobial and antifungal activities.