Synthesis and Antibacterial Activity of 2,3-Dihydro-4-(2'-Hydroxy-3'-Bromo-5'-Ethylphen-1'-yl)-2-Substitutedphenyl-1,5-Benzothiazepine Derivatives

Abstract

2-Aminothiophenol reacts with 2´-hydroxy chalcones in methanol and

acetic acid to give propiophenones which immediately undergo cyclization

to give 1,5-benzothiazepine derivatives. The structures of the compounds

have been confirmed by elemental analysis and spectral analysis. The

antibactarial activity of the compounds have been also screened.