Stability and Antimicrobial Studies of Mixed Ligand Complexes of Nickel(II) with SomeReactive Methylene Compounds and Carboxylic Acid

Abstract

The stability of simple and mixed complexes of Ni(II) with

oxalic acid (Ox^2–), N-(2-ethoxy) phenyl malonamic acid (EPM^–)

and N-(4-methyl) phenyl malonamic acid (MPM^–) have been

studied polarographically. Lingane's method DeFord and Hume's

method have been used to determine the composition and stability

constants of simple complexes and Schaap and McMaster's method

for the mixed systems in aqueous media. Antimicrobial studies of

ligands and their simple and mixed metal complexes were carried

out by screening them in vitro against bacterial species Escherichia

coli (gram -ve) and Staphylococcus aureus (gram +ve).