Synthesis of 2-Amino Dihydropyrimidines,Their Thiocarbamide Derivatives and Study of Their Antimicrobial Activity

Abstract

Various substituted acetophenones (I) were prepared by Fries

migration of substituted phenyl acetates. (I) on Claisen-Schmidt

condensation with substituted aromatic aldehydes in presence of

40% NaOH gave different substituted chalcones (II). (II) on cyclocondensation

with guanidine carbonate in ethylene glycol gave

2-amino-5,6-dihydro pyrimidines (III). (III) on reaction with phenyl

isothiocyanate in benzene gave respective thiocarbamide derivatives

(IV). Structures of compounds (III) and (IV) were confirmed

on the basis of elemental analysis, chemical properties and IR, NMR

and mass spectra. Antimicrobial activities of some of the synthesised

compounds was also studied.