Synthesis and Biological Activities of Substituted 1,2-Diazole Derivatives

Abstract

The synthesis and biological activities (antiinflammatory and

antimicrobial) of a number of 1,2-diazole derivatives are described. N¹ -

nicotinoyl-3-methyl-5-phenyl-4-sulpha/substituted phenylazo-1,2-diazoles

have been synthesised by the condensation of sulpha substituted

phenylazo-1-phenyl-1,3-butanedione with nicotinic acid hydrazide, using

glacial acetic acid as condensing agent. Pharmacological profile of the

compounds synthesised is described.