Synthesis of New Quinazoline-4-One Compounds of Medicinal Importance

Abstract

Some new quinazoline-4-ons (II-VII) have been synthesised

using different amino compounds, viz., ammonia, hydrazine

hydrate, urea, thiourea, formamide, guanidine carbonate, etc., with

different oxo-compounds. Further condensations of these

quinazolines were carried out using piperazine formaldehyde or

phenyl isothiocyanate. All the compounds were purified and the

structure of the products has been established by elemental analysis

and spectral data. (IR, ¹H NMR). Significant antimicrobial activities

were observed for some members of the series.