Kinetics and Mechanism of Oxidation of Methionine by Chloramine-T in Alkaline Medium in Presence of OsO4 Catalyst

Abstract

Kinetics and mechanism of oxidation of D-L methionine (Met)

by sodium N-chlorotoluene-p-sulphonamide (CAT) in alkaline

medium in presence of OsO₄ catalyst have been investigated at

30ºC, and the results are compared to the reaction without Os(VIII)

catalyst. The reaction rate shows a first order dependence each on

[CAT] and [methionine] and inverse fractional order on [OH^–] and

fractional order on [OsO₄]. Additions of halide ions and variation

of ionic strength and dielectric constant of the medium do not have

any significant effect on the reaction rate. Thermodynamic

parameters have been evaluated.