Synthesis and Antifungal Activity of N1-Nicotinoyl-3-Methyl-4-(substituted Azo)-1,2-Pyrazoline-5-One

Abstract

A novel series of N¹-nicotionyl-3-methyl-4-(sulpha/substituted phynyl azo)-1,2-pyrazoline-5-one have been synthesized by the condensation of sulpha/substituted phenyl azo ethyl-3-oxobutyrate with nicotinic acid hydrazide, using glacial acetic as condensing agent. Some of the products showed significant antifungal activity agianst C. albicans, C. neoformans, S. schenikkii, T. mentagrophytes and A. fumigatus.