Synthesis of Tetrahydro Pseudionone by a New Route and Synthesis of 2:6 Dimethyoxy Octane and Ethanethioal Ester of Levulinic Acid by Kobe Electrosynthesis Process in Aprotic Medium and Dilute Condition

Abstract

Tetraphydropseudoionone and 2:6 dimenthoxy-octane have been synthesized by cross kolbe reaction between cirtronellic acid and levulinic acid and dimerisation of 4-methoxy valeric acid. This gives a new route for the syntheses of dihydropseudo ionine and
rhodinolidol (similar to nerolidol). The work is in progress. Kolbe
electrosynthesis of phenylthioacetic acid gives by radical and carboniumion,
products such as PhSCH₂SPh etc. It was thought interesting
to study cross Kolbe reaction between levulic acid and
ethanethiol to get a Ketone CH₃COCH₂CH₂S.Et similar to the
product PhSCH₂S·Ph referred above. However only the ester
CH₃COCH₂COSC₂H₅ in 12 h at ambient temperature, in aprotic
medium and dilution, due to intimate vicinity of the acid and thiol.
Rapid removal of the water formed as 'H' and OH' ions from the
sphere of action, has favoured esterification in 20% yield on the
base of levulinic acid.