Effect of Solvent in the Synthesis of 4-Aroylisoxazolines
Corresponding Author(s) : B.B. Wankhade
Asian Journal of Chemistry,
Vol. 12 No. 4 (2000): Vol 12 Issue 4
Abstract
Different 3-aroylflavanones and 3-aroylcbromanones were
prepared by condensing 1,3-propanediones with aromatic aldehydes
by literature method. They were subjected to react with
hydroxylamine hydrochloride in pyridine and in ethylenediamine
medium to form respective 3,5-diaryl-4-aroylisoxazolines. Their
structures were confirmed by chemical properties, elemental and
spectral analysis. The yield and ease of formation of isoxazolines
in pyridine was compared with that in ethylenediamine. It has been
observed that ease of fonnation was enhanced and time required to
complete the reaction was lessened using ethylenediamine as a
solvent.
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