Synthesis, Characterization and applications of Some New 5-Substituted-4-Thiazolidinone-2-Thioxo Azo Derivatives

Abstract

4-Thiazolidinone-2-thioxo (I) has been refluxed separately with
untried phenylazo-salicylaldehydes to get some new chelating
5-substituted-4-thiazolidinone-2-thioxo azo derivatives (II-V). For
comparison the 5-(salicylidene) derivative (VI) has also been
explored. Their characterisation has been done by chemical and
spectral data. The azo derivatives (II-V) have been used in dyeing
a variety of fabrics and histological staining. The derivatives (II-VI)
have shown distinctive antimicrobial activity as antibacterial,
antifungal and antitubercular; and are capable of acting as specific
spot test and chromatographic spray reagents. Their toxicity effect
and insecticidal activity have been determined with respect to
mortality of mosquito larvae, culex and anopheles sp.