Synthesis and Biological Activity of Divalent Metal Chelates of Metronidazole

Abstract

The complexing behaviour of metronidazole (1H-imidazole-1-ethanol-
2-methyl-5-nitro) towards Co(II), Ni(II), and Cu(II) has been studied. The
complexes of the general formula ML₂X₂·2H₂O and CuL₄Cl₂ [where
M = Co(II) or Ni(II)], L = C₆H₉N₃O₃ (drug) as ligand) and X = Cl^- ] have
been prepared and characterised by elemental analysis, molar conductance,
magnetic susceptibility measurements, electronic and infrared spectral data.
They have also been tested for their antibacterial activities.