Visible Spectrophotometric Determination of Cefuroxime Sodium

Abstract

Two simple spectrophotometric methods (A and B) have been
developed for the determination of cefuroxime sodium in pure and
in its pharmaceutical formulations. Method A is based on the formation
of green coloured complex with ferric chloride and postassium
ferricyanide exhibiting maximum aborption at 765 nm,
whereas method B is based on the formation of blood red coloured
complex with ferric chloride and 1,10-phenanthroline having absorption
maximum at 510 nm. The results obtained are reproducible
and are statistically validated.