Extractive Spectrophotometric Determination of Cyclopentolate Hydrochloric

Abstract

Two simple and sensitive extractive spectrophotometric methods
have been developed for the determination of cyclopentolate hydrochloride
in bulk samples and in pharmaceutical preparations which
are based on the formation of coloured complexes of the drug with
reagents such as bromothymol blue and methyl orange. The ion pair
complexes formed were quantitatively extracted into .chloroform
under the experimental conditions. All the variables have been optimized
and the concentration measurements are reproducible within
a relative standard derivation of 1.0% and recoveries are 99-101 %.