Extractive Spectrophotometric Estimation of Ambroxol

Abstract

Three simple and sensitive extractive spectrophotometric methods
have been developed for the determination of ambroxol in pure
and in its dosage forms. The developed methods involve formation
of colored chloroform extractable complexes of drug with orange
II, bromocresol green, bromophenol blue in acidic medium. Extractable
complexes showed absorption maximum at 490 nm, 430
nm and 420 nm and showed linearity in concentration ranges of 5
to 40  μg/mL, 2.5 to 25  μg/mL and 5 to 40  μg/mL respectively.
Results were validated statistically and were found to be reproducible.