Synthesis of 1-Carboxamido-3,5-Diaryl-Δ2-Pyrazolines and Their Antimicrobial Study

Abstract

Nine chalcones were obtained by condensing acetophenones with
aromatic aldehydes in ethanolic NaOH. Their structures were confirmed
by physical as well as chemical methods. These chalcones
were then reacted with semicarbazide hydrochloride in presence of
aqueous alkali in ethanol to get 1-carboxamido-3,5-diaryl- Δ²-pyrazolines.
The structures of these compounds were established on the
basis of chemical properties and spectral analysis. These compounds
were subjected to antimicrobial tests against the test organisms:
Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Staphylococcus
aureus, Shigella dysentery and Salmonella typhi. It has
been found that the compounds containing chloro and dimethylamino
groups as substituents enhance the antimicrobial activity.