Synthesis and Biological Activities of Substituted 7-Chloroquinoline Derivatives, Part-II

Abstract

4,7-Dichloroquinoline was condensed with 4-aminoacetophenone

to get 4-amino-( 4-acetyl phenyl)-7 -cbloroquinoline; it was

condensed with aryl aldehydes to get chalcones. The chalcones were

treated with substituted hydrazines, hydroxylamine hydrochloride,

urea and thiourea to get pyrazolins, isoxazolin, pyrimidineone/thione.

4-Amino-(4-acetyl; phenyl)-7-chloroquinoline, 4-amino[2-propen-

1-one-1-phenyl-3-( 4-methoxy phenyl) ]-7 -chloroquinoline, 4-

amino-[3-(4-methoxy phenyl)-2-(substituted)-5-(phenyl)-3,4-dihy

dro-[1 ,5-dipyrazolin]: 7-chloroquinoline, 4-amino-[3-( 4-ethoxy phenyl)-

5-(phenyl)-3,4-dihydro- [1,5-d]-isoxazolin]-7- chloroquinoline

were prepared in this work.